A Look at the XVIVO System’s High Performance Incubators

Mark Holterman, MD is a former surgeon at Rush Medical Center that currently applies his expertise in pediatric surgery as a professor at the University of Illinois College of Medicine in Peoria. Prior to his current work, Dr. Mark Holterman served at the Children’s Hospital of Illinois, St Francis Medical Center.

While at the Children’s Hospital, Dr. Holterman helped complete the first trachea transplant for a child. Over the course of nine hours, a 32 month old korean toddler received a stem cell engineered trachea. The cutting edge operation also utilized a non-absorbable nanofiber tracheal scaffold and bioreactor from Harvard BioScience and a Biospherix XVIVO cell incubation and processing system.

The XVIVO cell incubation and processing system allows the cell structures to be grown and stored through a closed system with closed off hoods and cell incubators. Cell incubators of the system, which is modular in design, are integrated into the hood system to avoid contamination risk and reduce volatility. The system also allows additional cell incubators to be incorporated as needed, and each can be customized depending on the specific cell cultures.

For additional information on the XVIVO system, visit www.biospherix.com.

ADA Comes Out in Support of MDPP

A board-certified pediatric surgeon with nearly three decades of experience in the field, Mark Holterman, MD, currently serves as a professor at the University of Illinois College of Medicine. Committed to advancing medicine, Dr. Mark Holterman supports the efforts of the American Diabetes Association (ADA). 

Senior citizens in the United States a higher risk of developing type 2 diabetes, with more than 25 percent of those aged 60 and over living with the disease. That’s why the ADA recently came out in support of a major new initiative known as the Medicare Diabetes Prevention Program (MDPP). This program will serve as an awareness and intervention platform with the goal of reducing the rate of diagnosis by providing support to community providers who, in turn, will be better equipped to provide screening and other services to at-risk communities. 

The new program will not only help reduce the rate of type 2 diabetes in seniors but will also help deal with rising health care costs that come from treating the illness.

Alliance for Advancement of Cellular Therapeutics Calls for Registry

Working at the University of Illinois College of Medicine as a professor of surgery and pediatrics, Dr. Mark Holterman has an interest in the field of biotechnology. Mark Holterman, MD, serves on the board of several organizations, including the Alliance for the Advancement of Cellular Therapies (AACT).

One of the leading organizations supporting a Registry of Cell Therapy, AACT believes that establishing a well-curated registry will help address many of the common criticisms about the use of cell therapy, such as concerns about incomplete patient data and the variable quality of stem cells. The proposed registry would also ensure that stem cells are used only for valid treatment strategies according to review board protocols. 

With a registry, researchers also could address concerns about unreliable data by identifying standardized metrics to apply at uniform points in time by objective observers. Finally, the registry would allow the Food and Drug Administration to audit every aspect of stem cell research data to evaluate safety and efficacy.

Stem Cell Therapy as a Way of Addressing Neurodegenerative Disease

A physician with an extensive background in stem cell research, Dr. Mark J. Holterman engages with the University of Illinois College of Medicine at Peoria as attending pediatric surgeon and professor. Mark Holterman, MD, also guides the Alliance for the Advancement of Cellular Therapies as cofounder and seeks out strategies for advancing the field through dialogue with diverse constituencies including patients, scientists, elected officials, regulatory bodies, and health care organizations. 

Stem cell therapy has had a revolutionary role in advancing the treatment of various human diseases over the past three decades. In the 1980s, a landmark use of this type of therapy was employed in Mexico for the neurodegenerative condition Parkinson's disease (PD). Though outcomes were variable, the science has progressively advanced, with promising treatments for neurodegenerative diseases such as PD, Alzheimer’s disease, Huntington's disease, and amyotrophic lateral sclerosis coming online. 

With neurodegenerative diseases involving the structural and functional loss, or death, of neurons, such conditions share a number of similarities. Unfortunately, currently accessible neurosurgical and pharmacological approaches do not halt the progression of underlying degenerative processes. This makes stem cell therapy a vital area of research in combatting them.

IPSAC-VN Scholar Program Enhances Health Care Providers in Vietnam

A professor of surgery and pediatrics at the University of Illinois College of Medicine, Mark Holterman, MD, has published numerous peer-reviewed articles and abstracts on various medical and surgical concepts. Dr. Mark Holterman also supports the International Pediatric Specialists Alliance for the Children of VietNam (IPSAC-VN), a nonprofit that enhances medical care for children in Vietnam through collaboration from clinical teams and support personnel. The organization also enables health care providers in Vietnam to further their education through the IPSAC-VN Scholar Program. 

Scholars accepted into the program receive funding and resources to pursue a medical education at a US medical school accredited by the Accreditation Council for Graduate Medical Education (ACGME). Scholarship recipients receive a $2,500 grant toward the cost of educational expenses, travel, and room and board for a period of one to two months, during which time they will observe US clinical practices and engage in translation research. The program is open to both licensed and in-training nurses, physicians, and allied medical personnel. 

Program applicants must possess a good grasp of the English language and the ability to converse. Additionally, applicants must submit a letter of recommendation from their home institution that confirms their commitment to enhancing the institution’s quality of care. The IPSAC-VN and the host medical institution will also grant scholars who finish the program a certificate of completion.

AAP Offers Flood Cleanup Guidance

An experienced pediatric surgeon, Dr. Mark Holterman has served as a professor of surgery and pediatrics at the University of Illinois College of Medicine for the past six years. Outside of his work as an educator, Mark Holterman, MD, is a longtime member of the American Academy of Pediatrics. 

In the wake of recent hurricanes throughout the southeastern region of the United States, the American Academy of Pediatrics (AAP) released guidelines for communities to ensure children remain safe and healthy as cleanup efforts continue. 

According to AAP officials, children are especially vulnerable to illness as a result of exposure to toxic substances present in floodwaters that linger after a hurricane--contamination that remains even after the waters recede. To ensure safety, children should not be brought back to flood-affected school areas until the buildings and playground equipment have been thoroughly cleaned and sanitized. Additionally, drinking water should be restored and large items of debris cleared out before kids come back, and they should not be involved in the cleanup work in any capacity.

Signs that a Child May Have an Autoimmune Disorder

Pediatric surgeon Mark Holterman, MD, teaches medical students and residents as a professor at the University of Illinois College of Medicine. In addition to this, he researches a wide range of topics relating to pediatric surgery. Over the years, Dr. Mark Holterman has published dozens of papers and maintained a clinical interest in such topics as autoimmune diseases.

Although autoimmune disorders, such as Addison’s disease, type 1 diabetes, and multiple sclerosis, are rare among children, they can still occur. These conditions may appear either on their own or with another autoimmune disorder when present in children and may be caused by environmental factors, heredity, or hormonal factors. 

In most cases, children with autoimmune disease experience varying symptoms depending on the specific condition they have. However, parents can be on the lookout for signs that a child’s immune system is having problems. These signs include weight loss, low-grade fever, and fatigue. Children with an autoimmune disease may also develop rashes or skin lesions and their hair may become more brittle than usual.

Since many of these symptoms can be attributed to common illnesses, parents should make sure they know the cause behind their child’s illness. If no clear cause can be found, it’s a good idea to have a pediatrician check for illness. If they suspect that an autoimmune disease is to blame, they will refer the child to a specialist.

IPSAC-VN Sends New Groups of Medical Professionals to Vietnam

As CEO of Mariam Global Health, Mark Holterman, MD, concentrates on research in the field of regenerative medicine. The Illinois-based pediatric surgeon additionally serves as a medical team member at OSF HealthCare Children’s Hospital, and as a University of Illinois College of Medicine professor. Dr. Mark Holterman’s philanthropic memberships include a position on the board of the International Pediatric Specialists Alliance for the Children of Vietnam. Thanks to IPSAC-VN, some of the country’s most vulnerable children have a chance to have their medical needs met by generous physicians, nurses, and ancillary professionals who volunteer their time.

In recent news, IPSAC-VN sent seven teams of volunteers to Vietnam in March 2017. One team of these medical personnel went into the highlands, where they taught Vietnamese hospital staff in the intensive care unit and in the operating theater. Another group brought training and surgical materials to a Ho Chi Minh Hospital. This group focused on assisting with neonatal surgeries, oncology care, and urological surgery for pediatric patients. And the third group visited a larger, newly constructed pediatric hospital, where they made rounds alongside Vietnamese physicians and assisted in the more critical surgical cases. Thanks to this outreach, Vietnamese doctors have gained an array of new skills and techniques for treating their pediatric patients.

The Core Goals of IPSAC Vietnam

A pediatric surgeon who functions as a professor of surgery and pediatrics at the University of Illinois, Dr. Mark Holterman is a graduate of Yale and the University of Virginia, where he earned his MD. Further to his professional pursuits, Dr. Mark Holterman supports the International Pediatric Surgical Alliance for the Children of Vietnam (IPSAC-VN), a philanthropic organization that assists Vietnamese pediatricians in the provision of care to the children of Vietnam.

IPSAC-VN has two core goals, including providing educational opportunities to Vietnamese pediatricians, through training events, interactive sessions, and lectures. Additionally, the organization supports a number of training initiatives created by medical schools and hospitals in Vietnam.

Its second goal is to improve the quality of patient care via the provision of suitable equipment for Vietnamese pediatricians. IPSAC-VN also works closely with medical professionals in Vietnam to identify children who may have difficulty in accessing surgical treatment and assists in the creation of mechanisms that ensure such children attain access to proper care.

The Hannah Sunshine Foundation - Tucker Beau's Story

University of Illinois College of Medicine Professor Mark Holterman, MD, teaches surgical and pediatric classes. In addition to his work in teaching, Dr. Mark Holterman actively explores cellular therapies. He is also one of the early leaders of the Hannah Sunshine Foundation, which supports pediatric patients like Tucker Beau. 

Tucker Beau was diagnosed with systemic juvenile idiopathic arthritis at a very young age. In this type of chronic arthritis the immune system targets healthy tissues, resulting in inflammation. In addition to joint pain, children living with this condition often experience prolonged fevers and issues with internal organs. 

When Tucker Beau was very young, his illness prevented him from eating properly. As time went by, it kept him from doing the active things other children do, like ride a bicycle. Tucker Beau relied on his heroes, Batman and fellow patient Sarah, for support. 

Tucker Beau's parents sought out stem cell treatments through Celltex Therapeutics, hoping to try all possible avenues to find help for their son. Tucker Beau became the first child to receive treatment for the disease that relied on the patient's own stem cells. Today, he is able to ride his bike, play lacrosse, and go to school.

Hannah Warren Receives New Trachea Constructed of Stem Cells

Dr. Mark J. Holterman serves as a professor of surgery and pediatrics at the University of Illinois in Peoria. A member of the executive board of the Alliance for the Advancement of Cellular Therapies, Mark. J. Holterman, M.D., has a keen interest in the field of regenerative medicine. In 2013, he played a key role in a ground-breaking trachea transplant made of the patient’s own cells and bioengineered scaffolding.

Born with a rare condition called tracheal agenisis, Hannah Warren did not have the ability to breathe, swallow, eat, or drink on her own. On April 9, 2013, 32-month-old Hannah received an artificial windpipe constructed from her own stem cells and a synthetic scaffold. She was the first child who received a tissue-engineered, stem cell-based artificial trachea. The nine-hour surgery, completed by an international team of medical professionals at the Children’s Hospital of Illinois, was successful.

Transplants using organs constructed of a patient’s own stem cells eliminate the risk of rejection by a patient’s immune system as well as a lifelong dependency on immunosuppressive drugs.

Unfortunately, Hannah Warren passed away several months after her surgery from unrelated medical conditions revealed after the tracheal transplant.

The Hannah Sunshine Foundation - Sarah's Story

Professor Mark J. Holterman, MD, teaches classes in surgery and pediatrics at the University of Illinois College of Medicine. Alongside his academic duties, Dr. Mark J. Holterman is a pioneer in the field of cellular and regenerative therapies. He assisted in the creation of both the Alliance for the Advancement of Cellular Therapeutics and the Hannah Sunshine Foundation.

The Hannah Sunshine Foundation was inspired by three young people whose lives were changed by cellular and regenerative therapies. One of them, Sarah Hughes, was diagnosed with systemic juvenile idiopathic arthritis and dysautonomia at the age of 11 months. Ms. Hughes' autoimmune condition left her unable to gain weight, eat normally, stand for prolonged periods, or engage in many of the activities that young people typically get to enjoy.

At the age of 22, Ms. Hughes underwent regenerative therapy using her own adult stem cells. The biotechnology company Celltex Therapeutics collected a small sample of her fat, which was used to harvest stem cells. After reintroducing the stem cells to her body through an intravenous infusion, Ms. Hughes experienced significant improvements almost immediately. Today, she can not only eat without the help of a feeding tube, but also walk, swim, and ride horses.

Study Names Obesity Itself as Actual Cause of MLL Overgrowths

Mark J. Holterman, MD, serves as a professor at the University of Illinois College of Medicine. In addition to teaching classes in the fields of pediatrics and surgery, Dr. Mark J. Holterman maintains standing as a fellow of the American College of Surgeons.

A recent study published in the Journal of the American College of Surgeons reveals that abnormal lower extremity growths in morbidly obese individuals are the result of a condition called obesity-induced lymphedema (OIL), which is a disease directly caused by morbid obesity.

In the pilot study, researchers sought to find the connection between obesity and lower extremity overgrowths, as little information was previously known on the subject. The typical procedure has been surgical removal of these growths. Researchers found, however, that losing weight through natural means (diet, exercise) or in more difficult cases via bariatric surgery are now the preferred treatment of these growths rather than surgical removal.

The overgrowth condition is called massive localized lymphedema (MLL), and this study is the first to actually link the condition directly to OIL. The recommendation for patients with MLL growths is that they receive weight loss counseling, preferably non-surgical in nature, before surgical treatments are considered.

IPSAC Vietnam Scholarship Program Supports Physicians in Vietnam

 

Mark J. Holterman, MD, serves as a professor of surgery and pediatrics at the University of Illinois College of Medicine, where he is a member of the surgery department’s division of pediatric surgery. Outside his work with the university’s surgery department, Dr. Mark J. Holterman supports the International Pediatric Specialists Alliance for the Children of Vietnam (IPSAC-VN), which advances the quality of health care in Vietnam through the IPSAC Vietnam Scholarship Program.

Granting awards of $2,500 to eligible Vietnam-based medical persons, the scholarship program focuses on granting access to a tailored education to nurses, allied medical personnel, and licensed and in-training physicians. The scholarship enables recipients to attend a US-based medical institution approved by the Accreditation Council for Graduate Medical Education and covers educational expenses associated with clinical practices or translational research training for up to two months. Funds may also go toward travel and room and board.

Eligible applicants must possess a firm grasp of the English language and provide a letter of recommendation from their home institution that highlights the applicant’s dedication to quality health care. Award recipients will receive a certificate from the IPSAC-VN and the host medical institution upon completing the program, and must then return to their original institution in Vietnam. Certificates do not grant license to practice in the US, nor may they apply toward application for a US residency or fellowship program.

Medical Fields - Regenerative Medicine

 

A surgeon and researcher, Dr. Mark J. Holterman pursued original medical research funded through the Illinois Regenerative Medicine Institute. When not performing research, Dr. Mark J. Holterman teaches up-and-coming MDs as professor of surgery and pediatrics with the University of Illinois at Peoria College of Medicine.

Regenerative medicine seeks to address the underlying causes of illnesses by actually repairing damaged organs or replacing those that cannot be salvaged. Physicians who practice regenerative medicine may, for instance, use techniques to encourage slow-healing organs like the heart to heal faster or more effectively. They may also replace entire organs through transplantation procedures or help the body re-grow damaged tissues through cell-based treatments.

If advances in regenerative treatments continue, the future could hold medical wonders that can improve quality of life and longevity. Regenerative care could one day allow doctors to create functioning pancreases that could then be placed inside patients with diabetes, allowing them to produce insulin as normal. Similar breakthroughs may permit people with spinal injuries to walk unaided.

Mark J. Holterman, MD, PhD

Why did you choose to specialize in pediatric surgery?
All of the challenges and rewards of surgical problems in children.

What do you enjoy most about being a physician at the Children’s Hospital of Illinois? 
Working with other dedicated staff members who take pride in their work.

Tell us something interesting about yourself.
I grew up on a farm.

Tell us something about your family life.I have three sons in college.

Do you have any hobbies or interests outside of medicine? 
Medical mission work in Vietnam.

General Information

Languages: English, Spanish

Title(s): Professor of Surgery & Pediatrics – University of Illinois College of Medicine at Peoria

Medical Education: University of Virginia (Charlottesville, VA)

Internship(s): University of Virginia (Charlottesville, VA; 1988-1989)

Residency: University of Virginia (Charlottesville, VA; 1989-1993)

Fellowship(s): Pediatric Surgery – University of Washington (Seattle, WA; 1993-1995)

Board Certification(s): Pediatric Surgery – American Board of Surgery

Clinical Interests: Anorectal Malformations, Chronic Abdominal Pain, Airway Issues

Professional Memberships: American Diabetes Association, American Association of Clinical Anatomy, Association of Academic Surgeons, Federation of Clinical Immunology Societies, Pacific Association of Pediatric Surgeons

Awards & Recognition: Top Doctors in the Nation – Castle-Connelly, National Merit Scholar – Yale University, Medical Scientist Training Program – National Institutes of Health, Innovative Research Award – American Diabetes Association

Philosophy of Care: Find the problem and fix it.

Associated with: Children’s Hospital of Illinois, OSF Saint Francis Medical Center